Cell Cycle Cell Division and Inheritance Practice Questions | A-Level Biology

Cell Cycle Cell Division and Inheritance

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In a cultured mammalian cell line, the G2 DNA damage checkpoint is disabled by loss of function in a kinase required to inhibit entry into mitosis after double strand breaks. Cells are irradiated late in S phase and then observed by microscopy. Which outcome is most likely during the first mitosis after irradiation?

Select one option.

Cells arrest in G2 until all breaks are repaired, then enter mitosis with normal chromosome segregation
Cells enter mitosis with unresolved breaks, producing chromosome fragments and anaphase bridges that increase missegregation
Cells bypass S phase in the next cycle and divide with unreplicated chromosomes because replication licensing fails
Cells complete cytokinesis before metaphase because actin ring formation becomes uncoupled from nuclear division
Cells increase meiotic recombination frequency to repair breaks via crossing over between homologous chromosomes

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